Research

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Research Interests

Evolutionary computation
Multiobjective optimization
Systems biology and bioinformatics applications of the above

 

Research Projects, Past and Present

Algorithms and Analysis

  • ParEGO - Bayesian multiobjective optimization (MO) algorithm based on Jones et al's EGO [ More ]
  • MOCK - MO clustering algorithm incorporating automated model selection [ More ] [ Mockiato (student project) ]
  • Performance assessment of stochastic multiobjective optimizers [ More ]
  • Adaptive grid archiving - online efficient diversity-maintenance for MO [ More ]
  • Hypervolume-based archiving - online convergence and diversity for MO [ More ]
  • mQAP - The multiobjective quadratic assignment problem [ Benchmark instances ]
  • M-PAES - hybrid MO algorithm combining local and global search [ Paper ]
  • PAES - local search-based multiobjective optimizer [ More ]

Evolutionary Models and Frameworks

  • Ephemeral resource constraints in optimization [ More ]
  • CLEMO - Closed-loop evolutionary multiobjective optimization [ IEEE Magazine Article ]
  • Multiobjectivization - transform a fitness landscape to reduce local optima [ Paper ]
  • Landscape state machines - stochastic matrix models of fitness landscapes [ Papers ]
  • No-Free-Lunch theorems for MO [ Papers ]
  • Neutral evolution and redundancy [ Paper ]
  • Evolvability of replicators [ (1st Year) PhD student poster ] [ Animation A ] [ Animation B ]
  • Cooperation in spatially structured populations [  Paper ]

Applications

  • Radio Pulsar Detection (PhD project with Jodrell Bank) [ Paper ]
  • Maintenance scheduling in the power industry [ Benchmarks and Results ]
  • Evolution of Anti-inflammatory Combinatory Drugs [ Paper ] [ Poster ]
  • Protein structure prediction methods and investigations [ More ]
  • CLADE - BBSRC grant on Closed-loop aptamer directed evolution (Co-Investigator) [ More ]
  • MUSCLE - BBSRC grant on mass spectrometry optimization (Principal Investigator) [ More ]
  • Closed-loop optimization of analytical instruments [ Papers ]
  • Husermet - BBSRC grant on large-scale study of human disease (Co-Investigator) [ More ]
  • MCISB - Manchester Centre for Integrative Systems Biology (Co-Investigator) [ More ]
  • Chocolate production - Early-warning recognition of water damage in cocoa beans [ Paper ]
  • Constrained spanning trees in telecommunications optimization [ Papers ]
  • Small molecule structure elucidation from NMR spectra [ Paper ]
  • Drug manufacturability optimization [ More ]
  • Radiation therapy treatment planning [ Paper ]

Closed-loop optimization of anti-inflammatory combinatory therapies.
Link to Nature Chemical Biology paper.

 

 

MOCK multiobjective clustering and model selection
- Screenshot from Mockiato -