Unintended effects and their detection in genetically modified crops

Created by W.Langdon from gp-bibliography.bib Revision:1.4549

  author =       "F. Cellini and A. Chesson and I. Colquhoun and 
                 A. Constable and H. V. Davies and K. H. Engel and 
                 A. M. R. Gatehouse and S. Karenlampi and E. J. Kok and 
                 J. -J. Leguay",
  title =        "Unintended effects and their detection in genetically
                 modified crops",
  journal =      "Food and Chemical Toxicology",
  year =         "2004",
  volume =       "42",
  pages =        "1089--1125",
  number =       "7",
  abstract =     "The commercialisation of GM crops in Europe is
                 practically non-existent at the present time. The
                 European Commission has instigated changes to the
                 regulatory process to address the concerns of consumers
                 and member states and to pave the way for removing the
                 current moratorium. With regard to the safety of GM
                 crops and products, the current risk assessment process
                 pays particular attention to potential adverse effects
                 on human and animal health and the environment. This
                 document deals with the concept of unintended effects
                 in GM crops and products, i.e. effects that go beyond
                 that of the original modification and that might impact
                 primarily on health. The document first deals with the
                 potential for unintended effects caused by the
                 processes of transgene insertion (DNA rearrangements)
                 and makes comparisons with genetic recombination events
                 and DNA rearrangements in traditional breeding. The
                 document then focuses on the potential value of
                 evolving {"}profiling{"} or {"}omics{"} technologies as
                 non-targeted, unbiased approaches, to detect unintended
                 effects. These technologies include metabolomics
                 (parallel analysis of a range of primary and secondary
                 metabolites), proteomics (analysis of polypeptide
                 complement) and transcriptomics (parallel analysis of
                 gene expression). The technologies are described,
                 together with their current limitations. Importantly,
                 the significance of unintended effects on consumer
                 health are discussed and conclusions and
                 recommendations presented on the various approaches
  owner =        "wlangdon",
  URL =          "http://www.sciencedirect.com/science/article/B6T6P-4C004D3-3/2/aa7645e0537a1179bdf1f50aa4c376b3",
  URL =          "http://www.entransfood.com/products/publications/WG2_paper_rev1_19jan2004_unmarked.pdf",
  month =        jul,
  keywords =     "genetic algorithms, genetic programming",
  DOI =          "doi:10.1016/j.fct.2004.02.003",
  size =         "Review copy runs to 103 pages",
  notes =        "Metapontum Agrobios, SS Jonica Km 448.2, I-75010
                 Metaponto Matera, Italy.

                 Publication Types: * Multicenter Study * Review

                 PMID: 15123383 [PubMed - indexed for MEDLINE]

                 Brief mention of (Helen Johnson et al., 2000)

Genetic Programming entries for Francesco Cellini Andrew Chesson Ian Colquhoun A Constable H V Davies Karl-Heinz Engel A M R Gatehouse Sirpa Karenlampi E J Kok J -J Leguay