Computational methods to identify miRNA targets

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@Article{Hammell2010,
  author =       "Molly Hammell",
  title =        "Computational methods to identify miRNA targets",
  journal =      "Seminars in Cell \& Developmental Biology",
  year =         "2010",
  volume =       "21",
  number =       "7",
  pages =        "738--744",
  month =        sep,
  ISSN =         "1084-9521",
  DOI =          "doi:10.1016/j.semcdb.2010.01.004",
  URL =          "http://www.sciencedirect.com/science/article/B6WX0-4Y5GY3K-2/2/ee338722f9ce7b4b87a41bdd717fc22e",
  keywords =     "genetic algorithms, genetic programming, miRNA, miRNA
                 target prediction, Computational methods",
  abstract =     "MicroRNAs (miRNAs) are short RNA molecules that
                 regulate the post-transcriptional expression of their
                 target genes. This regulation may take the form of
                 stable translational or degradation of the target
                 transcript, although the mechanisms governing the
                 outcome of miRNA-mediated regulation remain largely
                 unknown. While it is becoming clear that miRNAs are
                 core components of gene regulatory networks,
                 elucidating precise roles for each miRNA within these
                 networks will require an accurate means of identifying
                 target genes and assessing the impact of miRNAs on
                 individual targets. Numerous computational methods for
                 predicting targets are currently available. These
                 methods vary widely in their emphasis, accuracy, and
                 ease of use for researchers. This review will focus on
                 a comparison of the available computational methods in
                 animals, with an emphasis on approaches that are
                 informed by experimental analysis of microRNA:target
                 complexes.",
  notes =        "survey",
}

Genetic Programming entries for Molly Hammell

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