A Model of Gene Expression and Regulation in an Artificial Cellular Organism

Created by W.Langdon from gp-bibliography.bib Revision:1.4340

  author =       "Paul J. Kennedy and Thomas R. Osborn",
  title =        "A Model of Gene Expression and Regulation in an
                 Artificial Cellular Organism",
  journal =      "Complex Systems",
  year =         "2001",
  volume =       "13",
  number =       "1",
  pages =        "33--59",
  keywords =     "genetic algorithms, genetic programming",
  URL =          "http://www.complex-systems.com/pdf/13-1-3.pdf",
  URL =          "http://www.complex-systems.com/abstracts/v13_i01_a03.html",
  size =         "27 pages",
  abstract =     "Gene expression and regulation may be viewed as a
                 parallel parsing algorithm---translation from a genomic
                 language to a phenotype. We describe a model of gene
                 expression and regulation based on the operon model of
                 Jacob and Monod. Operons are groups of genes regulated
                 in the same way. An artificial cellular metabolism
                 expresses operons encoded on a genome in a parallel
                 genomic language. This is accomplished using an
                 abstract entity called a spider. A genetic algorithm is
                 used to evolve the simulated cells to adapt to a simple
                 environment. Genomes are subjected to recombination,
                 mutation, and inversion operators. Observations from
                 this experiment suggest four areas to explore: dynamic
                 environments for the evolution of regulation,
                 advantages of time lags inherent in the expression
                 algorithm, sensitivity of our genomic language, and
                 noncoding regions on the genome. Issues relating to the
                 application of the expression model to evolutionary
                 computation are discussed.",

Genetic Programming entries for Paul J Kennedy Thomas R Osborn