Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity

Created by W.Langdon from gp-bibliography.bib Revision:1.3963

@Article{harrigan:2004:TXL,
  author =       "George G. Harrigan and Roxanne H. LaPlante and 
                 Greg N. Cosma and Gary Cockerell and Royston Goodacre and 
                 Jane F. Maddox and James P. Luyendyk and 
                 Patricia E. Ganey and Robert A. Roth",
  title =        "Application of high-throughput Fourier-transform
                 infrared spectroscopy in toxicology studies:
                 contribution to a study on the development of an animal
                 model for idiosyncratic toxicity",
  journal =      "Toxicology Letters",
  year =         "2004",
  volume =       "146",
  number =       "3",
  pages =        "197--205",
  month =        "2 " # feb,
  keywords =     "genetic algorithms, genetic programming, Bacterial
                 lipopolysaccharide, High-throughput infrared
                 spectroscopy, Idiosyncratic toxicity, Metabonomics",
  DOI =          "doi:10.1016/j.toxlet.2003.09.011",
  abstract =     "An evaluation of high-throughput Fourier-transform
                 infrared spectroscopy (FT-IR) as a technology that
                 could support a {"}metabonomics{"} component in
                 toxicological studies of drug candidates is presented.
                 The hypothesis tested in this study was that FT-IR had
                 sufficient resolving power to discriminate between
                 urine collected from control rat populations and rats
                 subjected to treatment with a potent inflammatory
                 agent, bacterial lipopolysaccharide (LPS). It was also
                 hypothesized that co-administration of LPS with
                 ranitidine, a drug associated with reports of
                 idiosyncratic susceptibility, would induce
                 hepatotoxicity in rats and that this could be detected
                 non-invasively by an FT-IR-based metabonomics approach.
                 The co-administration of LPS with {"}idiosyncratic{"}
                 drugs represents an attempt to develop a predictive
                 model of idiosyncratic toxicity and FT-IR is used
                 herein to support characterization of this model. FT-IR
                 spectra are high dimensional and the use of genetic
                 programming to identify spectral sub-regions that most
                 contribute to discrimination is demonstrated. FT-IR is
                 rapid, reagentless, highly reproducible and
                 inexpensive. Results from this pilot study indicate it
                 could be extended to routine applications in toxicology
                 and to supporting characterization of a new animal
                 model for idiosyncratic susceptibility.",
  notes =        "Pharmacia Corporation, GMax-Bio",
}

Genetic Programming entries for George G Harrigan Roxanne H LaPlante Greg N Cosma Gary Cockerell Royston Goodacre Jane F Maddox James P Luyendyk Patricia E Ganey Robert A Roth

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