Automatic creation of a genetic network for the lac operon from observed data by means of genetic programming

Created by W.Langdon from gp-bibliography.bib Revision:1.2031

@InProceedings{lanza:2000:ICSB,
  author =       "Guido Lanza and William Mydlowec and John R. Koza",
  title =        "Automatic creation of a genetic network for the lac
                 operon from observed data by means of genetic
                 programming",
  booktitle =    "First International Conference on Systems Biology
                 (ICSB)",
  year =         "2000",
  address =      "Tokyo",
  month =        "14-16 " # nov,
  organisation = "Japan Society for Bioinformatics",
  keywords =     "genetic algorithms, genetic programming, Biology,
                 genetic networks, reverse engineering, lac operon",
  URL =          "http://www.genetic-programming.com/jkpdf/icsb2000geneticnetwork.pdf",
  abstract =     "This paper demonstrates that it is possible to use
                 genetic programming to automatically create (reverse
                 engineer) a computer program representing the logic
                 underlying the genetic network for the expression level
                 of the lac operon (composed of the Z, Y, and A genes)
                 as measured by its mRNA. Genetic programming starts
                 with observed time-domain expression levels of two
                 genes (REPRESSOR or CAP) and the concentrations of two
                 substances (GLUCOSE or LACTOSE) and automatically
                 creates both a topological arrangement of conditional
                 and comparative functions as well as all necessary
                 numerical parameters of a genetic network whose
                 behavior matches observed time-domain data.",
  notes =        "ICSB-2000 8 Feb 2001 ghostview and our printers barf
                 at icsb2000gn.ps population size 10,000",
}

Genetic Programming entries for Guido Lanza William J Mydlowec John Koza