An Observational Study: The Effect of Diuretics Administration on Outcomes of Mortality and Mean Duration of I.C.U. Stay

Created by W.Langdon from gp-bibliography.bib Revision:1.3872

@Misc{oai:arXiv.org:1408.6553,
  title =        "An Observational Study: The Effect of Diuretics
                 Administration on Outcomes of Mortality and Mean
                 Duration of {I.C.U}. Stay",
  author =       "Daniele Ramazzotti",
  year =         "2014",
  month =        aug # "~11",
  bibsource =    "OAI-PMH server at export.arxiv.org",
  oai =          "oai:arXiv.org:1408.6553",
  keywords =     "genetic algorithms, genetic programming, statistics",
  URL =          "http://arxiv.org/abs/1408.6553",
  abstract =     "This thesis conducts an observational study into
                 whether diuretics should be administered to ICU
                 patients with sepsis when length of stay in the ICU and
                 30-day post-hospital mortality are considered. The
                 central contribution of the thesis is a stepwise,
                 reusable software-based approach for examining the
                 outcome of treatment vs no-treatment decisions with
                 observational data. The thesis implements, demonstrates
                 and draws findings via three steps: Step 1. Form a
                 study group and prepare modelling variables. Step 2.
                 Model the propensity of the study group with respect to
                 the administration of diuretics with a propensity score
                 function and create groups of patients balanced in this
                 propensity. Step 3. Statistically model each outcome
                 with study variables to decide whether the
                 administration of diuretics has a significant impact.
                 Additionally, the thesis presents a preliminary machine
                 learning based method using Genetic Programming to
                 predict mortality and length of stay in ICU outcomes
                 for the study group. The thesis finds, for its study
                 group, in three of five propensity balanced quintiles,
                 a statistically significant longer length of stay when
                 diuretics are administered. For a less sick subset of
                 patients (SAPS ICU admission score < 17) the
                 administration of diuretics has a significant negative
                 effect on mortality.",
}

Genetic Programming entries for Daniele Ramazzotti

Citations