My research is on the analysis of mouse models of rheumatoid arthritis using x-ray microtomography (micro-CT). As a PSIBS Ph.D project, it must incorporate elements from each of its core disciplines:

  • Physical sciences (x-ray microtomography, histology)
  • Biomedical sciences (animal handling, disease scoring, tissue dissection)
  • Computer science (construction of shape models, image registration and segmentation)

The aims of my research are as follows:

  • To optimise microCT imaging protocols for imaging small animals
  • To conduct imaging experiments using these protocols on different strains of healthy and diseased mice
  • To develop an "atlas" model for use in the registration and subsequent quantification of disease states

My research split across two research groups: